女，汉族，1992年2月生，江苏盐城人，博士，讲师，获得江苏省“双创博士”人才称号，长期从事脂质代谢及相关疾病的基础研究，发表高水平科技论文10余篇，主持国家自然科学基金1项，参与国家自然科学基金3项。
通讯地址：盐城市希望大道南路2号盐城师范学院海洋与生物工程学院，邮编：224051。
联系电话：17326112293
E-mail：weils@yctu.edu.cn
1. 学习经历
2016.7-2020.8，南京大学，模式动物研究所，生物学，博士；
2014.7-2016.6，南京大学，模式动物研究所，遗传学，硕士；
2010.9-2014.6，江南大学，药学院，制药工程，本科。
2. 工作经历
2022.1-至今，盐城师范学院，海洋与生物工程学院，讲师；
2021.7-2021.10，盐城市疾病预防与控制中心，微生物检验科，科员；
2020.10-2021.2，信达生物制药（苏州）有限公司，研发部，细胞株构建员。
3. 承担的教学任务
主讲细胞生物学、生物统计学、生物信息学等课程。
4. 主要研究方向
脂质代谢及相关疾病的基础研究。
5. 主要科研成果
（1）主持或参加的科研项目
1) 国家自然科学青年基金，PUFAs通过炎症抑制在热量限制延长寿命中的作用机制研究(82200976)，2023.1-2025.12，主持人；
2) 国家自然科学基金，苦物质及其受体T2R介导呼吸道平滑肌松弛的机制研究(32071121)，2021.1-2024.12，参与人；
3) 国家自然科学基金，非激活肌卫星细胞的体外扩增及其在肌肉衰老防治中的可能性应用(91849107)，2019.1-2021.12，参与人；
4) 国家自然科学青年基金，同源结构域相互作用蛋白激酶HIPK2通过调控YAP在肺癌中发挥促癌功能的研究(81802921)，2019.1-2021.12，参与人。
（2）近年来发表的论文(按时间倒序，*通讯作者)
1) Wei Zhao, Jie Sun, Liang-Yu Yao, Dong Hang, Ye-Qiong Li, Cai-Ping Chen, Yu-Wei Zhou, Xin Chen, Tao Tao, Li-Sha Wei, Yan-Yan Zheng, Xie Ge, Chao-Jun Li, Zhong-Cheng Xin, Yang Pan, Xin-Zhu Wang, Wei-Qi He, Xue-Na Zhang, Bing Yao, Min-Sheng Zhu*. MYPT1 reduction is a pathogenic factor of erectile dysfunction. Commun Biol. 2022 Jul 25;5(1):744.
2) Xin Chen, Tian-Tian Qiu, Ye Wang, Li-Yang Xu, Jie Sun, Zhi-Hui Jiang, Wei Zhao, Tao Tao, Yu-Wei Zhou, Li-Sha Wei, Ye-Qiong Li, Yan-Yan Zheng, Guo-Hua Zhou, Hua-Qun Chen, Jian Zhang, Xiao-Bo Feng, Fang-Yu Wang, Ning Li, Xue-Na Zhang, Jun Jiang, Min-Sheng Zhu*. A Shigella species variant is causally linked to intractable functional constipation. J Clin Invest. 2022 Jul 15; 132(14): e150097.
3) Yan-Yan Zheng, Ye Wang; Xin Chen, Li-Sha Wei, Han Wang, Tao Tao, Yu-Wei Zhou, Zhi-Hui Jiang, Tian-Tian Qiu, Zhi-Yuan Sun, Jie Sun, Pei Wang, Wei Zhao, Ye-Qiong Li, Hua-Qun Chen, Min-Sheng Zhu, Xue-Na Zhang*. The thymus regulates skeletal muscle regeneration by directly promoting satellite cell expansion. The Journal of biological chemistry. 2021, 298(1): 101516-101516.
4) Yeqiong Li, Yuwei Zhou, Pei Wang, Tao Tao, Lisha Wei, Ye Wang, Wei Wang, Yanyan Zheng, Zhihui Jiang, Tiantian Qiu, Wei Zhao, Jie Sun, Xin Chen, Xue-Na Zhang, Min-Sheng Zhu*. LIMK2 is required for membrane cytoskeleton reorganization of contracting airway smooth muscle. Journal of genetics and genomics. 2021, 48(6): 452-462.
5) Lisha Wei, Yan-Yan Zheng, Jie Sun, Pei Wang, Tao Tao, Yeqiong Li, Xin Chen, Yongjuan Sang, Danyang Chong, Wei Zhao, Yuwei Zhou, Ye Wang, Zhihui Jiang, Tiantian Qiu, Chao-Jun Li, Min-Sheng Zhu, Xuena Zhang*. GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism. The Journal of biological chemistry. 2020, 295(47): 15988-16001
6) Jie Sun, Yan-Ning Qiao, Tao Tao, Wei Zhao, Li-Sha Wei, Ye-Qiong Li, Wei Wang, Ye Wang, Yu-Wei Zhou, Yan-Yan Zheng, Xin Chen, Hong-Chun Pan, Xue-Na Zhang, Min-Sheng Zhu*. Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction. Front Physiol. 2020, (11): 593966-593966
7) Chen X, Gao YQ, Zheng YY, Wang W, Wang P, Liang J, Zhao W, Tao T, Sun J, Wei LS, et al. (2020). The intragenic microRNA miR199A1 in the dynamin 2 gene contributes to the pathology of X-linked centronuclear myopathy. The Journal of biological chemistry.
8) Tao T, Sun J, Peng Y, Wang P, Chen X, Zhao W, Li Y, Wei L, Wang W, Zheng Y, et al. (2019). Distinct functions of Trio GEF domains in axon outgrowth of cerebellar granule neurons. J Genet Genomics.
9) Sun J, Tao T, Zhao W, Wei L, She F, Wang P, Li Y, Zheng Y, Li Y, Wang W, et al. (2019). CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice. J Genet Genomics.
10) Tao T, Sun J, Peng Y, Li Y, Wang P, Chen X, Zhao W, Zheng YY, Wei L, Wang W, et al. (2019). Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth. The Journal of biological chemistry.
11) Sun J, Yang GM, Tao T, Wei LS, Pan Y, and Zhu MS*. (2018). Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography. J Vis Exp.
12) Wang P, Zhao W, Sun J, Tao T, Chen X, Zheng YY, Zhang CH, Chen Z, Gao YQ,She F, Li YQ, Wei LS, et al. (2017). Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma. J Allergy Clin Immunol.
13) 李恒，吴燕，魏利莎，李会*，张晓梅*，史劲松*，许正宏*．原生质体诱变提高亚麻刺盘孢ST对底物 DHEA的耐受性和转化率[J]．化工进展．2014．